![]() ![]() The incubation period, one of the most basic parameters, has been estimated as being up to 21 days (typically 5–10 days) primarily from the laboratory-acquired infections that occurred in 1967 in Europe what little information has been published about Marburg infections in the natural setting in Africa has been gleaned from isolated cases or small outbreaks (Table 1). It is necessary to prioritize obtaining more accurate epidemiologic data in future outbreaks greater use of COSI may facilitate an improved understanding of outbreak dynamics in Marburg and other diseases.ĭespite many years of experience with the viruses, little is known about several important epidemiologic parameters relating to the development of Marburg virus disease. The analysis was severely hampered by a lack of completeness in epidemiologic data. This study extends the maximum known incubation period of Marburg virus disease to 26 days. The median COSI was 11 days, with an interquartile range of 8 to 15. ![]() Thirty-eight cases were retained for COSI analysis. Incubation periods ranged from a minimum of 2 days in the case of two laboratory workers to a maximum of at least 26 days for a person-to-person household transmission. Seventy-six cases were retained for the incubation period analysis. Similar analysis was conducted for COSI, using only cases with unambiguous person-to-person transmission where both the primary and the secondary case patients had well-defined illness onsets. Incubation periods were calculated for person-to-person exposure, for laboratory-acquired infections, and for presumed zoonotic exposures. Methodsĭata were obtained from original outbreak investigation forms (n = 406) and from published data (n = 45). The analysis uses pooled data from all Marburg cases between 19 to develop estimates for the incubation period and the clinical onset serial interval (COSI). ![]() Despite many years of experience with the viruses, little is known about several important epidemiologic parameters relating to the development of Marburg virus disease. Marburg viruses have been responsible for a number of outbreaks throughout sub-Saharan Africa, as well as a number of laboratory infections. ![]()
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